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Coleman PJ
Formula: C20H25Cl2N3O2S
Wnt inhibitor
Smiles: CC(C)(O)[C@@H](O)CC[C@@H](C)[C@H]1CC[C@H]2/C(/CCC[C@@]21C)=C/C=C1/C[C@@H](O)CCC/1=C
1) and 5-HT-evoked increases in intracellular calcium (pIC50 = 10
Trametinib DMSO solvate - CAS# 1187431-43-1 Catalog No.:M10955-10 Coleman PJTrametinib, also known as GSK1120212, is a n orally bioavailable inhibitor of mitogen activated protein kinase kinase (MEK MAPK ERK kinase) with potential antineoplastic activity. Trametinib specifically binds to and inhibits MEK 1 and 2, resulting in an inhibition of growth factor mediated cell signaling and cellular proliferation in various cancers. MEK 1 and 2, dual specificity threonine tyrosine kinases often upregulated in various cancer cell
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